Hypercholinergic activity in LRRK2 Parkinson's disease
نویسندگان
چکیده
منابع مشابه
Contribution of GTPase activity to LRRK2-associated Parkinson disease
Mutations in the leucine-rich repeat kinase 2 (LRRK2, PARK8, OMIM 607060) gene represent the most common known cause of hereditary Parkinson's disease (PD) with late-onset and dominant inheritance. LRRK2 protein is composed of multiple domains including two distinct enzymatic domains, a kinase and a Ras-of-complex (Roc) GTPase, connected by a C-terminal-of-Roc (COR) domain, and belongs to the R...
متن کاملLRRK2 and Parkinson disease.
OBJECTIVES To review the molecular genetics and functional biology of leucine-rich repeat kinase 2 (LRRK2) in parkinsonism and to summarize the opportunities and challenges to develop interventions for Parkinson disease (PD) based on this genetic insight. DATA SOURCES Publications cited are focused on LRRK2 biology between 2004 and March 2009. STUDY SELECTION Literature selected was based o...
متن کاملLRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
Leucine rich repeat kinase 2 (LRRK2) is a Parkinson's disease (PD) gene that encodes a large multidomain protein including both a GTPase and a kinase domain. GTPases often regulate kinases within signal transduction cascades, where GTPases act as molecular switches cycling between a GTP bound "on" state and a GDP bound "off" state. It has been proposed that LRRK2 kinase activity may be increase...
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One of the characteristic symptoms of patients with Parkinson Disease (PD) is a rigidity of movement. These symptoms disappear after administration of Levodopa. However, the long-term use of levodopa causes involuntary movements (dyskinesia). A proper diagnosis requires an automatic, unsupervised method for the detection and classification of levodopa induced dyskinesia. The main problem, howev...
متن کاملMetabolomic Profiling in LRRK2-Related Parkinson's Disease
BACKGROUND Mutations in LRRK2 gene represent the most common known genetic cause of Parkinson's disease (PD). METHODOLOGY/PRINCIPAL FINDINGS We used metabolomic profiling to identify biomarkers that are associated with idiopathic and LRRK2 PD. We compared plasma metabolomic profiles of patients with PD due to the G2019S LRRK2 mutation, to asymptomatic family members of these patients either w...
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ژورنال
عنوان ژورنال: The Lancet Neurology
سال: 2018
ISSN: 1474-4422
DOI: 10.1016/s1474-4422(18)30073-5